老年人非小细胞肺癌三维适形放疗的疗效分析

Effect analysis on three dimensional conformal radiotherapy for elderly with non -small cell lung cancer

目的探讨三维适形放射治疗（3DCRT）对老年人非小细胞肺癌（NSCLC）的临床疗效和毒副反应。方法58例非小细胞肺癌患者采用三维适形放射治疗，照射剂量DT2．0Gy／次，5次／周，DT总量64Gy-70Gy；放疗后1—3个月行胸部CT检查评价疗效。结果58例患者中，完全缓解（CR）17例，部分缓解（PR）33例，稳定（SD）6例，进展（PD）2例，总有效率86．2％（50／58）；毒副作用以放射性食管炎及放射性肺炎为主，但均可耐受。结论三维适形放射治疗对老年人非小细胞肺癌患者的近期疗效较好，且不良反应较轻，可耐受。

Objective To evaluate the effect and toxicity of three - dimensional conformal radiotherapy （3DCRT） on non - small cell lung cancer（NSCLC） in elderly. Methods 58 patients with non - small cell lung cancer were radiated by 3DCRT, DT 2. 0Gy/T,ST/W, the overall DT64 -70Gy ;CT examination was performed in the 1 to 3 months followed - up period to verify the therapeutic effects. Results Among 58 patients, 17 patients were CR,33 patients PR,6 patients SD,2 patients PD. Total effective rate（CR ＋ PR） was 86.2% ,serious toxicity was found to be the radiation esophagitis and radiation pulmonitis,but tolerable. Conclusions 3DCRT was an effective and tolerable regimen for treatment of elderly non - small cell lung cancer.