急性腹泻患者粪便诺如病毒抗原检测及临床分析

Clinical study of and Norovirus antigen detection in feces from patients with acute diarrhea

目的探讨诺如病毒性腹泻患者的临床特点,了解粪便诺如病毒抗原检测在临床诊疗中的意义。方法2007年10月～2008年2月就诊于首都医科大学附属北京友谊医院肠道门诊的297例腹泻患者,留取粪便,采用ELISA检测诺如病毒抗原,并进行临床分析。结果297例腹泻患者,ELISA检测粪便,诺如病毒抗原阳性100例,阳性率为33.7%。结论诺如病毒感染是引起腹泻的重要原因之一,粪便诺如病毒ELISA检测为临床诊断该病提供了依据。

Objective To explore the clinical characteristics of Norovirus diarrhea and determine the levels of fecal No- rovirus antigens for clinical diagnosis. Methods Fecal specimens were collected from 297 patients with acute diarrhea seen at Beijing Friendship Hospital from 2007-10--2008-02. Norovirus antigens in the stool were detected by an enzyme- linked immunosorbent assay （ELISA）, and then data were analyzed. Results Of the 297 patients, 100 （33.7%） were positive for Norovirus detected by ELISA. Conclusion Norovirus is a major cause of diarrhea, and testing for fecal No- rovirus antigens is helpful in diagnosis of the disease.