慢性心衰患者心房颤动与血浆血管紧张素Ⅱ及醛固酮的关系

Correlation among plasma levels of angiotensin Ⅱ,aldosterone and atrial fibrillation in elderly patients with chronic heart failure

目的:观察老年慢性心力衰竭(CHF)合并心房颤动(Af)患者血浆肾素、血管紧张素Ⅱ(AngⅡ)以及醛固酮浓度的变化。方法:选择76例治疗后病情稳定的老年CHF患者,根据其是否合并Af分Af组(41例)和窦性心律组(35例),分别检测两组患者血浆肾素、AngⅡ以及醛固酮的浓度。结果:合并Af的老年CHF患者的血浆AngⅡ以及醛固酮浓度较窦性心律患者明显增高(P<0.05～<0.01)。结论:老年慢性心力衰竭患者心房颤动的发生可能与血浆血管紧张素Ⅱ以及醛固酮水平的增高有一定关系。

Objective： To investigate the correlation among plasma levels of angiotensin Ⅱ , aldosterone and atrial fibrillation in elderly patients with chronic heart failure. Methods： Seventy-six elderly patients with stable chronic heart failure were included in the present study. The plasma levels of renin, angiotensin （Ang） Ⅱ and aldosterone were detected in 41 patients with atrial fibrillation and in 35 patients with sinus rhythm. Results： The plasma levels of Ang Ⅱ and aldosterone in elderly patients with atrial fibrillation were significant higher than those of with sinus rhythm （P〈 0.05）. Conclusion： The plasma levels of angiotensinll and aldosterone may be participate in the development and persistence of atrial fibrillation in elderly patients with chronic heart failure.