槌果藤软膏治疗银屑病的实验研究

Experimental Investigations on the Action of Capparis spinosa L. Ointment for Treating Psoriasis

目的:观察槌果藤软膏对银屑病动物模型的疗效及其抗炎、止痒等作用。方法:观察计数小鼠尾部给药后鳞片表皮颗粒层形成情况;计数处于有丝分裂中期的阴道基底细胞有丝分裂数,并换算成有丝分裂指数;观察记录右旋糖苷致小鼠瘙痒次数及瘙痒持续时间;测定二甲苯致小鼠耳廓肿胀程度;测定小鼠腹腔毛细血管炎性渗出。结果:槌果藤软膏对小鼠尾部鳞片表皮颗粒层的形成具有显著的促进作用;可明显抑制小鼠阴道上皮细胞有丝分裂;能明显缓解右旋糖苷引起的小鼠瘙痒;减轻二甲苯致小鼠耳肿胀程度并抑制小鼠腹腔毛细血管通透性增高。结论:槌果藤软膏对小鼠银屑病模型有显著的治疗作用,并具有抗炎、止痒等作用。

Objective：To investigate the effect of Capparis spinosa L. Ointment on treatment for animal models＇ psoriasis, and to observe its anti-inflammative and itch-relieving actions. Methods： The percentage of the granular cells appeared on squamouis slices of mice tails was analyzed, the mitosis index of vaginal bottom cell in mitosis metaphase chromosome was counted, and times and duration of mice＇ s itching caused by dextran were observed. Auricle swelling caused by xylene and phlogistic exudation of celiac capillary vessel in mice were measured. Results ： Capparis spinosa L. Ointment possessed significant promoting effect on the formation of granular layer in mouse tail scale epidermis, showed significant inhibiting effect on mice vaginal epithelial mitosis, marked itch-relieving effect, alleviating effect on mice＇ s auricle swelling induced by xylene and restraining effect on mice＇ s celiac capillary vessel permeability. Conclusion： These results indicate that Capparis spinosa L. Ointment has effect on treatment for psoriasis in mouse models, and it also has effects of anti-inflammation and analgesia on the experiment mice.