鸡骨草胶囊对大鼠肝纤维化的保护作用研究

Study on the Protective Effects of Jigucao Capsule in Rat Liver Fibrosis

目的:探讨鸡骨草胶囊对肝纤维化大鼠的影响,为临床适应症提供实验依据。方法:采用40%CCl4(v/v)皮下注射法建立大鼠肝纤维化模型,用不同浓度的鸡骨草胶囊混悬液灌胃干预。结果:鸡骨草胶囊可改善造模大鼠的肝功能,使肝纤维化大鼠降低的血清总蛋白(TP)、白蛋白(ALB)值升高;可改善肝纤维化大鼠的血清抗氧化指标,血清中超氧化物岐化酶(SOD)含量增加,丙二醛(MDA)含量降低;并可减轻肝脏组织病理损伤程度,使肝纤维化大鼠病理学评分值降低。结论:鸡骨草胶囊对大鼠实验性肝纤维化具有明显保护作用,能明显减轻肝纤维化程度。

Objective：To research the influence of Jigucao Capsule to rat liver fibrosis, to provide a experimental basis for the expansion of clinical indications. Methods： Rat liver fibrosis model by 40 % CCl4 （v/v） subcutaneous injection was built up, and intervented with different concentrations of Jigucao Capsule suspensionorally. Results：Jigncao Capsule could improve the liver function of model rat, and increase serum TP, ALB. It could improve the rat serum antioxidant indicators, increase serum SOD content, and reduce the MDA content. It could reduce the pathological changes of the liver damage to show a lower value of liver fibrosis. Conclusion：Jigncao Capsule showed apparent protective effect to rat with liver fibrosis. It could significantly reduce the degree of liver fibrosis.