复方鳖甲软肝片联合恩替卡韦治疗慢性乙型肝炎疗效观察

Observation on Therapeutic Efficacy of Treating Chronic Hepatitis B with Compound BieJiaRuanGan Pill plus Entaeavir

目的观察复方鳖甲软肝片联合恩替卡韦对慢性乙型肝炎患者肝功能、免疫功能及血清纤维化指标的影响。方法将168例患者随机分为两组，对照组口服恩替卡韦，治疗组在对照组治疗基础上，加服复方鳖甲软肝片，48周为1个疗程。结果两组治疗前后肝功能、外周血T淋巴细胞亚群和血清肝纤维化指标比较均有统计学意义（P〈0．01或P〈0．05），治疗后组间比较治疗组优于对照组（P〈0．01或P〈0．05）。结论复方鳖甲软肝片联合恩替卡韦治疗慢性乙型肝炎有效。

Objective To observe the therapeutic efficacy of Treating chronic hepatitis B with compound BieJiaRuanGan pill plus entacavir. Methods 168 patients were randomly recruited into a treatment group and a control group. The treatment group was treated with compound BieJiaRuanGan pill plus entacavir and the control group was treated with entacavir exclusively, with a course of 48 weeks. Results Both groups showed statistical significance in improving the liver function, peripheral T lymphocyte subsets and indexes of serum liver fibrosis after the treatment （P〈0.01 or P〈0.05） . The therapeutic effects in the treatment group were significant better than the control group after the treatment （P〈0.01orP〈 0.05） . Conclusion The treatment of chronic hepatitis B with compound BieJiaRuanGan pill plus entacavir is better than using entacavir exclusively.