增补叶酸预防神经管缺陷效果及其影响因素

Efficacy of folic acid supplementation and fortification to prevent neural tube defects and its influencing factors

育龄妇女增补叶酸是预防神经管缺陷(neural tube defects,NTDs)的重要措施之一。本文综述了叶酸现场干预试验、人群推广叶酸增补剂以及叶酸食品强化等叶酸增补方式预防NTDs的效果,分析了预防效果差异的原因及其影响因素。结果可为叶酸干预NTDs的策略与措施及其效果的科学评价提供参考依据。

Folie acid supplementation is one of the most important measures to prevent neural tube defects （NTDs） among child-bearing age women. This article reviews the NTDs prevention efficacy of the studies including field intervention trials, population folic acid supplementation and fortification in different countries, and analyzes the efficacy variation and their influencing factors of the related studies. The results of the article may provide references for folic acid supplementation, fortification and its efficacy evaluation in the population.