大鼠射频损毁治疗靶点脑局部血氧饱和度(SO_2)变化特性研究

Change of hemoglobin oxygen saturation (SO_2) of rat's brain tissue in radio-frequency damage

神经外科脑毁损术中靶点局部生理参数实时监控非常重要,目前手术疗效还没有一种可靠的实时评估指标,为此进行初步探索。采用SD大鼠为实验对象,对大鼠脑部治疗靶点进行局部射频毁损,利用微创近红外光谱技术实时测量局部血氧饱和度,考察其毁损过程中的变化规律。实验结果表明血氧饱和度在可逆与不可逆毁损时表现出不同的变化特性,通过对实验数据的统计分析,找到了一些基本规律,这些结果对立体定向射频毁损实时疗效评估具有一定的参考价值。

During the neurosurgery brain damage surgery, real-time monitoring of the target＇s regional physiological parameters is very important. There isn＇t a credible method on real-time evaluation rule at present. Some elementary research was carried out in this aspect. SD rats were chosen as experiment object. The target of treatment local of rat brain was damaged with radio-frequency, and minimally invasive nearinfrared technology was used to measure hemoglobin oxygen saturation in situ on real-time. The changes in the process of radio-frequency damage were studied. The different changes of hemoglobin oxygen saturation were studied in reversible damage and irreversible damage. At the same time, some basic law was found on the analysis of a large number of experiment parameters. The results have some efficacy in certain reference value in future damage of stereotactic radio-frequency real-time assessment.