摘要
RNA结合蛋白(RBP)是决定细胞分化、活动力和其他过程的调节子。LIN28是一种高度保守的RBP,在线虫和高等物种中有着复杂的调节机制和表达方式。它对微小RNA表达的调节、骨髂肌及心肌分化、肿瘤形成、多潜能诱导等多种发育的重要事件中起关键作用。本文就LIN28的研究进展予以综述。
RNA-binding proteins（RBP） are important regulators which determine the cell differentiation,motility and other processes.Lin-28,a highly conserved RNA-binding protein with a complex mechanism of regulation both in nematodes and in higher species,plays key role in regulating miRNA expression,differentiation of skeletal and cardiac muscle,tumorigenesis and inducing pluripotent.This paper reviewed the advances in the studies of LIN28.
出处
《医学综述》
2009年第20期3055-3058,共4页
Medical Recapitulate
