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Visfatin的研究进展

Recent Progress in Visfatin Research
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摘要 Visfatin是一种在内脏脂肪组织高表达的脂肪细胞因子,具有类胰岛素、调节免疫及炎症、促进脂肪分化及合成等多重生物学作用。目前普遍认为肥胖及2型糖尿病(T2DM)等代谢性疾病均伴随低度系统性慢性炎性反应,而visfatin可能是联系炎症及代谢性疾病的环节之一。深入研究vis-fatin与炎症的关系可能为T2DM及肥胖的治疗提供新靶点。 Visfatin is a novel adipocytokine highly expressed in visceral adipose tissue,which has insulin-like effect,regulating immunity and inflammation and promoting the differentiation and synthesis of fatty tissue.The recent researches showed that mtabolic disease such as type 2 diabetes mellites（T2DM）and obesity are low,systematic and chronic inflammation.Visfatin may be the link connecting inflammation and Metabolic disease.Lucubrating the relationgship between visfatin and inflammation may provide a new target for the treatment of obesity and type 2 diabetes mellites.
作者 黄丽芳 荣海钦
机构地区 山东省内分泌与代谢病研究所
出处 《医学综述》 2009年第20期3080-3082,共3页 Medical Recapitulate
关键词 VISFATIN 炎症 2型糖尿病 胰岛素抵抗 肥胖 Visfatin Inflammation Type 2 diabetes mellites Insulin resistance Obesity
分类号 R587.1 [医药卫生—内分泌]
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参考文献26

  • 1Fukuhara A, Matsuda M, Nishizawa M, et al. Visfatin : a protein secreted by visceral fat that mimics the effects of insulin [ J ]. Science,2005,307(5708 ) :426-430.
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二级参考文献13

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  • 4Chen MP, Chung FM, Chang DM, et al. Elevated plasma level of visfatin/pre-B cell colony-enhancing factor in patients with type 2 diabetes mellitus. J Clin Endocrinol Metab, 2006,91:295-299.
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医学综述
2009年 第20期

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