摘要
结肠癌的高发病率成为严重的社会医疗问题,因而对于癌前病变和早期癌的诊断至关重要。虽然有效的检查手段很多,但是在致癌分子机制不断完善的基础上发展非侵入性的筛查技术值得高度关注。通过对结肠癌发病机制及病理生理的研究,目前分子检测的重点在于对粪便中的肿瘤细胞以及它们所携带的癌基因、抑癌基因的DNA突变的检测。本文主要介绍一些诊断结肠癌的非侵入性检查手段,其高灵敏度和特异度非常有助于结肠癌的早期诊断。
High prevalence of colon cancer will be a serious socio-medical problem.Hence,the diagnosis for precancerous change and early carcinoma are important.Despite a variety of efficacious instrumental diagnostic tools,the development of non-invasive screening techniques based on the progress in carcinogenesis molecular mechanisms which deserves height attention.Through the research to pathogenesy and physiopathologic in colon carcinoma,the emphasis of molecule detection are considered in the detection of tumour cells in faeces,the carrying oncogenes and DNA mutation in anti-oncogene.The paper will introduce non-invasive inspection to diagnose colon carcinoma.the high sensitivity and specificity of these methods will help to the early diagnosis of colon carcinoma.
出处
《医学综述》
2009年第20期3083-3086,共4页
Medical Recapitulate
基金
南京医科大学科技发展基金面上项目资助(08NMUM094)
关键词
结肠癌
筛查
早期诊断
Colon cancer
Screening
Early diagnosis
