血管紧张素转化酶抑制剂抗心肌纤维化作用的研究进展

Research Advancement of Angiotensin Converting Enzyme Inhibitor on Inhibiting Myocardial Fibrosis

心肌纤维化是以心脏间质成纤维细胞过度增殖和胶原过度沉积及异常分布为特征的心脏间质重构。血管紧张素转化酶抑制剂在抗高血压、逆转心室肥厚、心室重构等心血管疾病中发挥重要作用。近年来发现其抗心肌纤维化作用明显,但其详细机制尚不清楚。本文就其抗心肌纤维化作用及研究进行综述。

Myocardial fibrosis is featured by excessive proliferation of cardiac fibroblast and collagen deposition.Angiotensin-converting-enzyme-inhibitors（ACEIs） play an important role in treating hypertension,reversing ventricular hypertrophy and remodeling structure of ventricles.Recent studies show that ACEIs have obvious effect on inhibiting myocardial fibrosis,but the precise mechanism remains unclear.In this paper,a summary review is given about the researches.