硝酸异山梨酯联合丹参川芎嗪对心肌缺血性ST-T改变的作用

Efficacy of Isosorbide Dinitrate Joint with Salvia Ligustrazine on Myocardial Ischemic ST-T Changes

目的观察注射用硝酸异山梨酯联合丹参川芎嗪注射液治疗心肌缺血性ST-T改变的临床效果及安全性。方法将126例有明确心肌缺血性改变的患者随机分为治疗组和对照组,两组均给予常规的抗心肌缺血的口服药对症治疗,治疗组在此基础上同时应用硝酸异山梨酯及丹参川芎嗪注射液静脉滴注。结果治疗前后,两组患者收缩压、舒张压及心率间差异均有统计学意义(P<0.05);治疗后,两组患者收缩压、舒张压及心率间差异亦均有统计学意义(P<0.05)。两组患者疗效及显效时间比较,差异均有统计学意义(P<0.05)。结论硝酸异山梨酯与丹参川芎嗪静脉应用可明显改善心功能,扩张冠状动脉,改善心内膜下血流,及时纠正心肌缺血所致改变,减少不良反应,值得临床推广。

Objective To investigate the clinical efficacy and safety of isosorbide dinitrate joint with salvia ligustrazine on myocardial ischemic ST-T changes.Methods 126 cases of myocardial ischemia who had a clear ST-T changes were randomly divided into treatment group and control group,conventional oral drugs for curing myocardial ischemia were given in both two groups.At the same time,isosorbide dinitrate and salvia ligustrazine injection were added to the treatment group.Results Differences of systolic pressure,diastolic pressure and heart rate were statistically significant before or after treatment（P〈0.05）.There were differences of systolic pressure,diastolic pressure and heart rate between the two groups after treatment（P〈0.05）.The therapeutic effect and cure time were statistically different between the two groups（P〈0.05）.Conclusion The drug combination of isosorbide dinitrate and salvia ligustrazine can improve cardiac function,coronary artery ectasia and subendocardial blood flow,and can reverse ST-T changes caused by myocardial ischemia in time,reduce side effects,thus is worthy to be popularized.