120例鼻喉部恶性肿瘤血清唾液酸检测分析

Ananysis on the value of sialic acid levels in the diagnosis of 120 cases of cancers in nose and throat

目的探讨血清唾液酸(SA)水平对鼻喉部肿瘤诊断的应用价值。方法采用高特异性UV法(日本Wako公司试剂盒)对100例健康对照者,120例鼻喉部良性疾病患者和90例鼻喉部恶性肿瘤患者检测血清SA浓度,比较两组间血清SA水平差异。结果鼻喉部恶性肿瘤组血清SA水平显著高于健康对照组及良性疾病组,差异有统计学意义(P<0.001),良性疾病组与健康对照组间SA水平差异无统计学意义(P>0.05)。结论血清SA测定对鼻喉部恶性肿瘤的辅助诊断具有一定的参考价值。

Objective To investigate the clinical value of sialic acid levels in diagnosis of cancers in nose and throat. Methods 100 normal controls and 120 patients with benign disease in nose or throat were selected, and 90 patients with cancer in nose or throat were included. The UV method was used to determine the levels of serum sialic acid. Results The sialic acid levels of patients with nose or throat cancer were significantly higher than those of normal controls and patients with benign disease in nose or throat （（P〈0. 001）. There was no statistical difference between normal controls and patients with benign disease（P〉0.05）. Conclusion Determination of serum SA was valu able in diagnosis of cancer in nose and throat.