血清一氧化氮检测在肺癌诊断中的临床意义

The clinical applications of detecting the nitric oxide in serum of the patients with lung cancer

目的探讨血清中癌胚抗原(CEA)和一氧化氮(NO)水平在肺癌中的表达及其诊断价值。方法采集肺癌患者血清100例,良性肺病患者血清80例,并与80例健康人作比较。应用化学发光免疫分析法和硝酸还原酶法分别检测血清中的CEA和NO。结果肺癌患者血清中CEA和NO分别是(39.42±24.61)ng/mL、(123.30±25.21)μmol/L,明显高于良性肺病组(8.21±3.42)ng/mL、(99.12±21.61)μmol/L及健康对照组(7.31±4.30)ng/mL、(77.81±17.61)μmol/L,P均小于0.01。结论肺癌血清中CEA和NO水平显著升高,提示CEA与NO参与了肺癌的发生和发展,故CEA和NO检测是肺癌患者非常有用的辅助诊断指标。

Objective To explore the expressions of serum carcino embronic antigen （CEA） and nitric oxide （NO） and their diagnosis value for lung cancer. Methods The levels of serum CEA were tested by radio- immunoassay and NO by biochemistry in 100 patients with lung cancer, among which 80 patients with benign lung diseases and 80 people in healthy group. The data was analyzed. Results The levels of serum CEA and NO in patients with lung cancer were （39.42±24.61）ng/mL, and （123.30±25.21）μmol/mL, which significantly higher than those （7.31±4.30 ng/mL, 99.12±21.61μmol/mL） in patients with benign lung diseases and also higher than those （7.31 ±4.30 ng/mL, 77.81±17.61μmol/mL） in healthy group （P〈0.01）. Conclusion Increasing levels of serum CEA and NO indicated that CEA and NO cansed the incidence and development of lung cancer. CEA and NO are the available supplementary indexes in diagnosis of lung cancer.