精神分裂症患者异常脑网络的fMRI研究

An fMRI Study of Aberrant Brain Network in Schizophrenia Patients

目的:比较正常组和精神分裂症患者组执行工作记忆任务时的脑激活差别,探讨精神分裂症患者执行功能障碍的脑机制。方法:对16例正常对照和16例精神分裂症患者进行数字3-back工作记忆任务的fMRI检查和数据分析处理。结果:患者组出现两个激活方向相反的脑区网络,与正常组相比激活降低脑区为双侧DLPFC、VLPFC、LPMA、PPC、PFC嘴侧部和额极及左侧SMA;激活增加脑区为MPFC、双侧颞叶和双侧扣带回。结论:精神分裂症患者执行功能损害有相应的病理生理学基础,是多个脑区功能受损、脑网络连接障碍而非单一脑区受损,前额叶与海马/颞叶-边缘皮层间功能连接破坏可能是其中的一个原因。

Objective： To compare the difference in brain activation between schizophrenia patients and normal controls, to explore the neural basis of executive impairement in schizophrenia patients. Methods： Sixteen schizophrenia patients and sixteen normal controls received a 3-back working memory task. fMRI data ahalysis was applied. Results： Schizophrenia patients showed two activation networks with different orientation. Compared with normal controls, schizophrenia patients showed decreaed activity in multiple regions including bilateral DLPFC, VLPFC, LPMA, PPC, left SMA, rostral part and frontal pole of PFC, while increased activity in MPFC, bilateral temporal lobe and cingulate. Conclusion： Impaired executive function in schizophrenia patients may have underlying pathophysiological basis. Schizophrenia patients are associated with function damage of multiple regions and functional disintegration of brain network but not single brain region. Aberrant functional connectivity between prefrontal cortex and hippocampus/ temporolimbie cortices may be one of the reasons.