我院6种临床常见病原菌耐药性分析

Analysis of Drug Resistance of Six Common Pathogenic Bacteria in our Hospital

目的:了解我院2008年上半年6种常见致病菌对不同类型抗菌药的耐药情况,为临床合理使用抗菌药提供依据。方法:对临床送检标本中培养分离的6种常见致病菌:大肠埃希菌、铜绿假单胞菌、肺炎克雷伯菌、金黄色葡萄球菌、鲍曼不动杆菌和嗜麦芽窄食单胞菌进行分析,并与2006～2007年度全国细菌耐药监测结果进行对比。结果:我院抗菌药对金黄色葡萄球菌的抗菌作用好于全国平均水平;革兰阴性杆菌对第三代、第四代头孢菌素的耐药率明显高于全国平均水平,与该类药物存在大量不合理应用有关。结论:细菌耐药呈上升趋势,开展细菌耐药监测对指导临床合理应用抗菌药具有重要意义。

Objective： To study the antibiotic resistance of six common pathogenic bacteria in our hospital in the first half of 2008 and guide the rational use of antibiotics. Method： An analysis was conducted of six common pathogenic bacteria： escherichia coli, pseudomonas aeruginosa, klebsiella pneumoniae, staphylococcus anreus, acinetobaeter baumannii and stenotrophomonas maltophilia cultured and isolated out of the specimens submitted for detection by the clinical departments, and a comparative analysis was conducted with Mohnarin （ Ministry of Health National Antibacterial Resistance Investigation Net）in 2006 -2007. Result： The antimicrobial activity of antimicrobial agents against staphylococcus aureus in our hospital was better than the national average. The gram-negative bacilli resistance of the third and fourth generation cephalosporin was significantly higher than the national average, which was related to the irrational use of a large number of drugs. Conclusion： Bacterial resistance rates are on the rise, and therefore, great importance must be attached to bacterial resistance monitoring so as to provide a guidance for the rational clinical use of antibacterials.