奥美拉唑联合凝血酶治疗上消化道出血的疗效观察

Combined Use of Omeprazole and Thrombin in Treatment of Upper Gastrointestinal Bleeding

目的探讨奥美拉唑联合凝血酶治疗上消化道出血的疗效。方法对我院2008年3月～2009年2月收治的100例上消化道出血患者,随机均分为治疗组及对照组。所有患者均给予补充血管容量及必要的对症治疗,两组皆用奥美拉唑静脉滴注,治疗组在上述治疗基础上加用凝血酶口服,疗程7d。结果两组患者经过治疗后,治疗组总有效率为90.0%,治疗组总有效率为78.0%,两组总有效率比较,差异存在显著性(P<0.05);且两组未发现明显毒副作用。结论奥美拉唑与凝血酶联合应用在上消化道出血有良好的止血效果,且不良反应少,值得推广应用。

Objective To investigate the therapy efficacy of omeprazole combined with thrombin in the treatment of upper digestive tract hemorrhage. Methods One hundred patients with upper gastrointestinal bleeding treated in our hospital from March 2008 to Feb. 2009 were randomly divided into treatment group and control group. All patients were given the necessary vascular capacity complement and symptomatic treatment,intravenous omeprazole was given to the two groups and oral thrombin was added to the treatment group for 7d. Results The total effective rate of the treatment group was 90.0%, and that of the control group was 78.0%, with a significant difference between the two groups （P 〈 0.05）,and the two groups showed no obvious side effects. Conclusion Omeprazole in combination with thrombin for gastrointestinal bleeding has a good hemostatic effect,and fewer adverse reactions,worthy of popularization.