血清SCC-Ag、NSE、CA125联合检测对肺癌的诊断价值

Diagnostic value of combined detection of serum SCC-Ag、NSE and CA125 levels for hung cancer

目的探讨血清肿瘤标志物SCC-Ag、NSE和CA125在肺癌诊断中的临床价值。方法分别测定82例肺癌患者、38例肺良性疾病患者、30例健康人血清中的SCC-Ag、NSE和CA125水平。结果肺癌患者组的三种肿瘤标志物水平均高于肺良性疾病患者组和正常对照组(P<0.05)。其中血清中SCC-Ag、NSE、CA125的敏感性分别为64.6%、43.9%、40.2%,三者联合检测的敏感性为86.6%。SCC-Ag在鳞癌的敏感性最高为75.0%;NSE在小细胞未分化癌敏感性最高为78.6%;CA125在腺癌的敏感性为76.9%。结论血清SCC-AG、NSE和CA125检测有助于临床对肺癌的诊断,并对组织分型有较高的参考价值。

Objective To appraise the clinical value of SCC-Ag, NSE and CA125 in the diagnosis of lung cancer. Methods Serum levels of SCC-AG,NSE,CA125 in 82 patients with lung cancer,38 patients with benige lung diseases and 30 normal controls were measured. Results The levels of SCC-Ag, NSE, CA125 in lung cancer group were significandy higher than those in benign lung diseases and normal control groups（ P 〈 0. 05 ）. Sensitivities of SCC-Ag, NSE and CA 125were 64. 6% ,43.9% , and 40. 2% , respectively. Sensitivity of combined detection of three kinds tumor markers was 86.6%. Of three markers,sensitivity of SCC-Ag was the highest（75.0% ） in patients with lung squamous cell carcinoma. Sensitivity of NSE was the highest（78.6% ） in patient with small cell undifferentiated car-cinoma of lung. And sensitivity of CA125 was the highest（76.9% ） in patients with lung adenoearcinoma. Conchusions The Serun levels of SCC-Ag, NSE and CA125 are helpful in diagnosis of lung cancer and Especially. It is Valuable to differentiating various histological type of lung cancer.