阻塞性睡眠呼吸暂停综合征与高血压临床分析

Clinical analysis of the relationship between obstructive sleep apnea syndrome and hypertension

目的探讨阻塞性睡眠呼吸暂停综合征与高血压的相关性。方法20例患者经多导睡眠图(PSG)检查,符合OSAS的诊断标准[1],同时伴有高血压作为试验组。另20例为单纯高血压病患者作为对照组。两组患者均常规低盐饮食,口服药物治疗3周,比较治疗前后血压变化;OSAS组降压效果差的患者同时接受持续气道正压通气(CPAP)治疗,观察血压控制情况。结果药物治疗3周后,对照组晨起血压较治疗前明显下降(P<0.05);OSAS组药物治疗前后无明显变化,再同时用(CPAP)治疗3周后晨起血压明显下降。结论OSAS患者与其高血压具有相关性,与OSAS有关的高血压患者单纯药物治疗效果欠佳,CPAP治疗对这种高血压有效。

Objective To explore the relationship between obstructive sleep apneasyndrome （OSAS） and hypertension. Methods Patients with hypertension were given polysomnography examination （PSG）, coincident with diagnostic criterion of OSAS （experimental group）, 20 patients of single hypertention were controls. Two groups condueted low sait diet and medicine for three weeks. The measures of their blood pressures were compared before and after the treatment. The OSAS group with poor results in terms of pressure control was given CPAP for three weeks, and the ehanges of blood pressure were observed. Results After the first three weeks treatment, the pres- sure of the control group was decreased remarkably （ P 〈 0. 05 ）. However the experimental group was not deferred from before and after the treatment. After using CPAP for 3 weeks, the blood pressure in the morning after night sleep was significantly decreased as eompared with that before the treatment （P 〈 0. 05）. Conclusion The OSAS patients are correlated with hypertension. The OSAS patients could not get good result by using medication only. CPAP treatment is effective for the treatment of the hypertension.