阿尔茨海默病患者的脑电图和脑血流分析

Analysis of electroencephalogram and cerebral blood flow in patients with Alzheimer disease

目的探讨阿尔茨海默病(AD)患者的脑电图(EEG)和脑血流(CBF)表现,评价其与诊断、预后及治疗的关系。方法对93例经临床确诊的AD患者进行EEG和经颅多普勒超声(TCD)检查,分析EEG异常程度与痴呆严重程度的关系,以及AD患者的脑血流改变。结果93例患者中EEG正常4例,占4.3%;异常89例,占95.7%。患者痴呆程度越重,EEG异常也越明显。AD组MCA及BA的峰值流速(Vp)、平均流速(Vm)较对照组低,而血管搏动指数(PI)则较对照组高,差异有统计学意义(P<0.05和P<0.01)。结论EEG、TCD检查对AD的诊断、鉴别诊断、预后判断及指导治疗有实用价值。

Objective To investigate the characteristics of electroencephalogram（EEG） and cerebral blood flow（CBF） of patients with Alzheimer disease（AD） and evaluate the relationship between EEG abnormalities and patients＇ prognosis, prognosis as well as CBF and treatment.Methods EEG and transcranial Doppler（TCD） was performed in 93 patients with AD proved by clinic. The relationship between degree of EEG abnormalities and patients＇ prognosis as well as the change of CBF was analyzed. Results Of the EEG of 93 cases involved in the study,4（4.3%） was normal,89（95.7%） had abnormalities. The higher degree of EEG abnormality,the severer degree of dementia.Comparisons With control group,the systole peak flow velocity（Vp） and mean flow velocity（Vm） in AD group were dropped,while the pulsating index（PI） enhanced（ P〈0.05 or P〈0.01 ）.Conclusions EEG and TCD is worthy for the diagnosis, differential diagnosis, deciding prognosis and directing treatment of AD.