降脂宁颗粒治疗高脂血症性脂肪肝的实验研究

Jiangzhining Granules in Treatment of Hyperlipidemia Fatty Liver in Rats:An Experimental Study

目的:观察中药成方制剂降脂宁颗粒对高脂血症性脂肪肝大鼠的干预效果,为临床治疗高脂血症性脂肪肝提供实验依据。方法:采用高脂乳剂灌胃复制大鼠高脂血症性脂肪肝模型,将大鼠分为正常组,模型组,降脂宁高、中、低剂量组,以二甲双胍和血脂康为对照组,实验结束后检测大鼠血清和肝脏中脂质含量,同时采用光镜和电镜检测肝脏病理变化。结果:与模型组相比,降脂宁高、中剂量组大鼠血清和肝脏中脂质含量明显减少,同时肝脏病理切片显示降脂宁高、中剂量组大鼠肝脏的脂肪化程度得到明显改善。结论:降脂宁颗粒能有效地防治高脂血症性脂肪肝。

Objective： To observe the effects of Jiangzhining Granules, a patent traditional Chinese medicine, on hyperlipidemia fatty liver in rats, and provide an experimental basis for the treatment of hyperlipidemia fatty liver. Methods： The rat model of hyperlipidemia fatty liver was induced by intragastrie injection of high fat emulsion. The rats were randomized into normal group, model group, metfomin group, Xuezhikang group and Jiangzhining Granules groups （further randomized into high, middle, low dose group）. At the end of experiment, the contents of iipids in the serum and the liver of rats in all groups were assayed, at the same time, the pathological changes of the liver were observed under light microscope and electron microscope. Results： The contents of lipids in the serum and the liver of rats in high and middle dose groups of Jiangzhining Granules were decreased compared with those in model group. At the same time, the pathological section under light microscope and electron microscope showed that the pimelosis of rat liver was attenuated in high and middle dose groups of Jiangzhining Granules. Conclusion： Jiangzhining Granules can effectively prevent and treat hyperlipidemia fatty liver.