乙型肝炎相关性肝病肝移植术后影响因素分析

An analysis of the factors influencing the survival rate of liver transplantation patients with previous hepatitis B related diseases

目的分析原位肝移植治疗乙型肝炎相关性肝病长期生存率的影响因素,探讨其干预对策可行性。方法回顾性分析同济医院器官移植研究所2002年8月至2005年8月行肝移植治疗的乙型肝炎相关肝病75例的临床资料及随访结果。结果通过Logistic回归分析,术前人工肝治疗、抗病毒治疗、有效的肿瘤化疗方法、原发病为肝癌和术后并发症对于病人肝移植术后的长期生存率有影响。结论肝移植手术是治疗乙型肝炎相关性终末期肝病的有效方法,人工肝治疗、抗病毒治疗、肿瘤化疗干预及积极防治术后并发症可以提高病人术后长期生存率。

Objective To analyze the factors influencing the long survival rate of liver transplantation patients with previous hepatitis B related diseases and assess the efficiency of medical interventions. Methods The clinical data of 75 liver transplantation patients with previous hepatitis B related diseases from Aug. 2002 to Aug. 2005 were retrospective analyzed. Results The Logistic regression analysis demonstrated that preoperative artificial liver treatment, anti-virus treatment, effective chemotherapy,hepatocellular carcinoma（HCC）and postoperative complications influenced the long survival rate of liver transplantation patients with previous hepatitis B related diseases. Conclusion The liver transplantation is an effectual treatment for with previous hepatitis B related diseases, and the long survival rate can be improved by artificial liver treatment,anti-virus treatment,chemotherapy for HCC and postoperative complications prevention.