摘要
报道了一种新的5-氟尿嘧啶衍生物2-噻吩甲酸(5-氟尿嘧啶-1-基)甲酯的合成.用1HNMR、13CNMR、IR对其进行了结构表征,通过单晶X射线衍射确定了晶体结构,同时分析了热性质.晶体属单斜晶系,空间群为P2/c,晶胞参数为:a=9.6134(14),b=4.8381(7),c=24.534(4),α=90°,β=97.289(3)°,γ=90°;Z=4,F(000)=552,R1=0.0616.
A new 5-fluorouracil derivative, (5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl) methyl thiophene- 2-carboxylate, has been synthesized. Its structure has been characterized by means of ^1H NMR, ^13C NMR, IR. Single crystal was diffracted with X-ray to ascertain the crystal structure of the compound. And the thermal feature of the compound was analyzed. Crystal data are shown as following: monoclinic, space group P2/c, a = 9.613 4(14) A, b = 4.838 1(7) A, c = 24.534(4) A, α = 90°, β = 97.289(3)°, γ = 90°, Z = 4, F(000) = 552, R1 = 0.061 6.
出处
《温州大学学报(自然科学版)》
2009年第5期34-39,共6页
Journal of Wenzhou University(Natural Science Edition)
基金
国家自然科学基金资助项目(20571057)
浙江新苗人才计划资助项目(2008R40G2250104)
关键词
5-氟尿嘧啶
2-噻吩甲酸
晶体结构
热分析
5-Fluorouracil
2-Thiophene Acid
Crystal-structure
Thermo-gravimetric Analysis