体外照射联合^252Cf中子后装治疗T1、T2期鼻咽癌的临床研究

Clinical study of external beam radiotherapy combined with californium-252 neutron after loading intracavitary radiotherapy in the treatment of patients With T1 and T2 nasopharyngeal carcinoma

目的比较单纯常规体外照射与体外照射联合^252Cf中子后装治疗T1、T2期鼻咽癌原发灶的局部控制疗效和并发症。方法对30例初治的T1期和部分T2期鼻咽癌病例进行体外照射联合^252Cf中子后装治疗。结果全部病例随访2年，鼻咽局部复发2例，2年局部控制率93．3％，远处转移4例，张口困难2例，无一例患者发生软腭穿孔。结论体外照射联合^252Cf中子后装治疗鼻咽癌，增加了鼻咽腔内照射剂量，提高了局部控制率，减少了鼻咽癌外照射剂量，有利于降低张口困难的发生率。

Objective The results and side effects of nasopharyngeal carcinoma treated by combined external radiotherapy and Californium -252 neutron after loading intraeavitary radiotherapy. Methods From November 2005 to March 2007, 30 nasopharyngeal carcinoma patients with staged T1 and T2 by 1992 Fuzhou staging system, were treated by external beam radiotherapy combined with Californium-252 neutron after loading intracavitary radiotherapy. Results All patients were followed up for 2 years. 2 cases recurred in the nasopharynx. 4 cases developed distant metastases. 2 cases developed trismus. No perforations in hand and soft palate occurred. Conclusion External beam radiotherapy combined with Californiun-252 neutron after loading intracavitary radiotherapy for nasopharyngeal carcinoma is indicated for boosting the dose to the nasopharyngeal cavity; reducing the dose for external irradiation. It can improve local control rate of nasopharyngeal carcinoma and reduce occur rate for the trismus.