清胆胶囊与养肝利胆颗粒对豚鼠胆色素结石炎症反应环节的影响

Effects of "Qingdan Capsule" and "Yanggan Lidan Granule" on Inflammatory Reaction in Guinea Pigs with Pigmented Gallstones

目的:观察两种不同治则的中药清胆胶囊和养肝利胆颗粒对豚鼠胆色素结石形成过程中炎症环节的影响。方法:应用雄性豚鼠建立胆色素结石模型,分别观察清胆胶囊和养肝利胆颗粒对该模型成石率、胆囊容积、胆汁中黏蛋白浓度及C反应蛋白(CRP)浓度等指标的影响。结果:清胆胶囊组与养肝利胆颗粒组成石率均显著降低(P<0.01),胆囊容积明显减小(P<0.05);胆汁中黏蛋白及CRP浓度明显降低(P<0.05),两种中药制剂对黏蛋白及CRP的影响无统计学意义。结论:清胆胶囊与养肝利胆颗粒对胆色素结石有良好的防治作用,而且二者在干预胆色素结石病炎症反应环节上的作用效果和机制基本相似。

Objective： To study the effects of ＂QingDan Capsule＂ （ QDJN ） and ＂Yanggan Hdan Granule＂ （YGLD） which follow different therapeutic principles on inflammatory reaction in guinea pigs with pigmented gallstones. Methods ： Animal model of pigmented gallstones was reproduced in male guinea pigs by hypodermic injection of lincomycin. Then the stone formation rate, gallbladder volume, mucin and C-reactive protein in bile were measured respectively. Results：Compared with model group, the rates of stone formation, gallbladder volume and mucin and C-reactive protein in both QDJN and YGLD groups were significantly decreased（P 〈0.01 or P 〈0.05 ）. There was no significant difference between QDJN and YGLD groups in mucin and C-reactive protein. Conclusion：Both QDJN and YGLD have good preventive and therapeutic effects for model guinea-pigs with pigmented gallstones, and their pharmaceutical effects and related mechanisms on inflammatory reaction are basically similar.