内镜下射频联合药物治疗胃黏膜脱垂疗效观察

An observation of radio frequency ablation combined with drug therapy for gastric mucosa prolapse

目的观察内镜下射频联合药物治疗胃黏膜脱垂疗效,为胃黏膜脱垂的治疗寻找有效方法。方法对经过胃镜、胃肠钡餐造影检查确诊为胃黏膜脱垂的65例患者随机分为治疗组和对照组。治疗组:先采取内镜下对脱垂的胃黏膜进行射频点灼治疗,然后服用雷贝拉唑,10mgbid×28d,铝镁加混悬液15mltid×28d;对照组:不予射频治疗,服药与治疗组相同。两组均于疗程结束后复查胃镜判断疗效。结果治疗组32例,治愈率为94%,总有效率达97%;对照组33例,治愈率为18%,总有效率为39%,治疗组和对照组相比在治愈率和总有效率差异有统计学意义(P<0.01)。两组治愈病例随访6个月,治疗组无复发,对照组有3例复发。结论内镜下射频联合雷贝拉唑、铝镁加混悬液疗效好,不良反应少,易于推广。

Objective To explore an effective methads for the treatment of gastric mucosal prolapse（GMP）, the therapeutic effect of endoscopic radiofrequency ablation combined with drug for GMP was observ. Methods 65 cases of patients with GMP confirmed by gastroscopy and gastrointestinal barium meal examination were randomly divided into treatment group and control group. Treatment group： the prolapsed gastric mucosa was firstly cauterized by endoscopic radiofrequency ablation, then the patients were give Rabeprazole and Almagate suspension taken. Control group： medication was the same as treatment but groupwithout radiofrequency ablation. The therapeutic effect of both groups were evaluated after the above - endoscopic mentioned therapeutics. Results There were significant differences between treatment group（n =32） and control group（n=33） in the cure rate（94% and 18%, P 〈0.01） and the total effective rate （97% and 39% ,P 〈 0.01）. There were 3 cases of recurrence in control group and no recurrence in treatment group by following up the curative cases of both groups for 6 months, Conclusion Endoscopic radiofrequency ablation combined with Rabeprazole and Ahnagate suspension is a method with high efficiency,less adverse reactions and convience promote.