摘要
最近研究发现一类不同于Th1和Th2的CD4^＋T细胞亚群-Th17细胞亚群。白介素6（IL-6）及转化生长因子β（TGF-β）是促进Th17分化的关键细胞因子。转录调节因子孤核受体是特异性调节Thl7分化及功能的转录调节因子。目前慢性阻塞性肺疾病（chronic obstructive pulmonary disease，COPD）的发病机制未明，慢性气道炎症特别是中性粒细胞的募集和激活被认为在COPD的发病中占有重要作用。Th17细胞通过其主要效应因子IL-17刺激IL-6、IL-8、粒巨噬细胞集落刺激因子及巨噬细胞炎性蛋白2等前炎症细胞因子招募中性粒细胞，同时促使气道黏液高分泌，调节气道重构，最终作用到相应的靶器官。随着Th17细胞研究的深入，有助于进一步阐明COPD的发病机制。
Recently a third group of cells termed Th17 has been identified. These cells follow a distinct differentiation profile requiring TGF-β and IL-6 leading to the expression of the Th17 selective transcription factor, RORγt. The pathogenesis of chronic obstructive pulmonary disease （COPD） is not entirely known. Chronic inflammation is a key feature of many airway diseases. Leukocyte accumulation in the lung has the capacity to mediate many aspects of the path physiology of COPD. IL-17 is the main effect factor of Th17 cells. It can stimulate pro-inflammatory cytokines such as IL-6,IL-8,GM-CSF and MIP-2 to recruit neutrophils. At the same time,airway mucus hypersecretion and regulation of airway remodeling also attribute to IL-17. With the research on Th17 cell,we can know more about the pathogenesis of COPD.
出处
《国际呼吸杂志》
2009年第19期1178-1181,共4页
International Journal of Respiration
