高迁移率族蛋白B1在肺部疾病中的研究进展

Advance study on high-mobility group box 1 in lung diseases

高迁移率族蛋白B1具有增加抗原的免疫原性、促进炎症介质基因表达及炎症介质的释放、促进树突状细胞和Th1细胞极化成熟与促进纤维分化的功能，其在脓毒症、肾肝纤维化、动脉粥样硬化、血管损伤后再狭窄、神经发育、肿瘤转移以及类风湿性关节炎等疾病中起重要作用，而其是否在肺部疾病中起作用的研究尚开始，现就高迁移率蛋白B1在肺部疾病的研究进展作一介绍。

High-mobility group box 1（HMGB1） has the ability to increase the expression of genes for proinflammatory factors and secretion of proinflammatory factors, increase immunogenieity of antigens, promote maturation of DC and Th1 polarization and promote proliferation of fibroblasts. And it plays an important role in sepsis, renal or hepatic fibrosis, arteriosclerosis, vascular restenosis after injury, nerve development and rheumatoid arthritis. But the study on relationship between HMGB1 and lung diseases is still at the beginning stage. The article aims to instruct the advance on relationship between HMGB1 and lung diseases.