滤泡性细支气管炎研究进展

Progress of research on follicular bronchiolitis

滤泡性细支气管炎是一个组织病理学诊断，以细支气管壁伴有生发中心的淋巴样滤泡增生为特征。常与慢性感染和炎症性气道疾病，例如囊性纤维化、支气管扩张、慢性误吸、结缔组织疾病、包括获得性免疫缺陷综合征在内的免疫缺陷综合征有一定的相关性。在胸部影像学主要表现为两肺小结节或网状阴影，伴有胸腔内淋巴结肿大，结节和毛玻璃样影可以两肺弥漫性分布，主要位于支气管血管周围。结合临床表现和影像学表现可以用于滤泡性细支气管炎的诊断。治疗缺乏特效治疗手段，一般预后较好。

Follicular bronchiolitis is a histopathologieal diagnosis,and is characterized with follicular hyperplasia in lymphoid germinal center and bronchiole wall. It is often associated with chronic infections and inflammatory airway diseases such as cystic fibrosis, bronchiectasis, chronic aspiration, connective tissue diseases,including immunodeficiency syndrome like AIDS. Chest imaging mainly manifests small nodules or reticular shadow, accompanied with intrathoracic lymph nodes, nodules and ground-glass shadow diffuse distribution in both lungs,located at the bronchial perivascular tissues. Clinical manifestations and imaging can be used to make the diagnosis of follicular bronchiolitis. It is usually lack of treatment means but have a good prognosis.