帕金森氏病患者丘脑腹外侧核毁损术后脑脊液中单胺类递质含量的变化

CSF monoamine changes in patients with Parkison's disease after stereotactic destruction of thalamoventrolateral nucleus

目的：观察帕金森氏病患者脑立体定向术前、后脑脊液中神经递质水平的变化，这种变化的作用机理如何。方法：对１５例帕金森氏病患者丘脑腹外侧核毁损术前及术后一周脑脊液中单胺类递质水平检测及手术疗效观察。结果：患者术后脑脊液中多巴胺水平与术前无显著差异，而５－羟色胺、去甲肾上腺素、５－羟吲哚乙酸显著减少，术后毁损区对侧上下肢体震颤、肌强直消失，但运动不能症状未能改善。结论：帕金森氏病术后中枢多种神经递质发生改变并在低水平下暂时获得平衡。从中枢神经递质生化变化。

Objective: To observe the monoamine changes in the brain of patients with Parkinson's disease before and after stereotactic neurosurgery Methods: The levels of monoamines in the cerebrospinal fluid (CSF) of 15 patients with Parkinson's disease (PD) before and one week after stereotactic destruction of thalamoventrolateral nucleus were determined and the operation effect were observed Results: The CSF 5 hydroxytryptamine, 5 hydroxyindoleacetic acid and noradrenaline after operation were significantly lower than those before There was no significant changes when referring to dopamine Tremor, rigidity of the contralateral upper and lower limbs disappeared after the destruction of thalamoventrolateral nucleus, but the akinedia was not improved Conclusions: Several neurotransmitters in the brain of the patients after operations were altered and reached to a new balance on a lower level Therefore, stereotactic operation was not a complete relief for PD patients