促生素治疗克罗恩病的循证研究

The evidence-based study of probiotics in the treatment of Crohn’s disease

目的通过复习文献从流行病学和循证医学的角度研究促生素治疗克罗恩病的效果。方法检索近年来研究促生素治疗克罗恩病的临床证据的文献,进行评价。结果促生素治疗克罗恩病的作用不太明显,但提示促生素在克罗恩病的治疗方面有较好的前景。结论从循证医学的角度对过去的研究文献进行质量评价,具有较高质量级别的文献(设计良好的RCT的Meta分析)目前尚未有,大样本多中心质量较高的临床试验也非常有限。因此,仍然需要一些高质量的随机对照实验进一步明确促生素在克罗恩病预防和治疗方面的作用。

Objective To study the effect of probiotics in the treatment of Crohn s disease from the epidemiology and evidence-based medical science perspectives. Methods Through comprehensively retrieving related studies about probiotics in CD, collected systematically assess and analysed these studies. Results From the epidemiology and evidence-based medical science perspectives, probiotics didn t achieve good effect on CD, but some researching finding were also encouraging and promising. Conclusion The researches of good quality of RCT Meta-analysis didn＇t have currently, and big scale of multiple center collaboration clinical trials are also very limited, therefore, some high quantities of RCTs are still needed to further examine the efficacy of probiotics in CD.