干预趋化因子治疗缺血性脑损伤

Intervening Chemokines For The Treatment of Ischemic Brain Damage

大量研究证实趋化因子参与缺血性脑损伤的病理生理过程。它们或者促进炎症反应,加重脑损伤,或者诱导神经干细胞迁移,促进损伤修复。因此拮抗趋化因子及其受体的作用,敲除趋化因子及其受体基因,以及促进其对神经干细胞的靶向作用有可能治疗缺血性脑损伤。广谱趋化因子拮抗剂的开发,趋化因子基因和蛋白表达的调控都有希望的方法,需要加强探索。

Lots of research confirmed that chemokines participate in the process of ischemic brain damage. On one side, they promoted inflammation thus aggravate brain injury, On the other side, they induced migration of neural stem cells to the ischemic region for neural reparing. So blocking chemokines and their receptors, knocking out genes of chemokines and their receptors and promoting the target-specific functions of neural stem cells might help treat ischemic brain damage. Broad spectrum antagonists for chemokines should be developed. In addition, controlling gene and protein expression of chemokines might also be a hopeful approach and needs to be further explored.