MEBO改善烧伤早期创面瘀滞区微循环的实验研究

Experimental Research on the Microcirculation Improving Effect of MEBO on Burn Wound Stasis Zone at the Early Stage

采用SD大鼠Ⅲ度烧伤模型，观察MEBT对烧伤早期创面瘀滞区微循环血量的影响，以探讨MEBT改善烧伤创面微循环的机制。96只SD大鼠随机分成MEBT组和传统干燥暴露疗法组，用激光多谱勒血流仪监测两组烧伤后创面瘀滞区微循环血量。结果烧伤后两创面瘀滞区微循血量急剧下降，2h降到最低，但传统干燥暴露疗法组在烧伤后各时相下降幅度显著大于MEBT组。14d观察到传统干燥暴露疗法组瘀滞区坏死面积明显大于MEBT组。证实MEBO可改善创面瘀滞区微循环，减轻烧伤早期创面进行性损害作用，显著增加瘀滞区的成活面积。

In order to investigate the microcirculation improving effect of MEBO, experimentalmodel of SD rat third degree burn was used.. 96 SD rats were divided in random into two groups,MEBT group and conventional dry exposed therapy group. Microcirculation blood flow in the stasiszone was measured using a Deppler Laser Blood Flow Meter, at 5 min, 30 min, and 1, 2, 4, 8, 12,18, 24, 48 and 72 hours post burn. The results revealed that in both groups, microcirculation in stasiszone decreased greatly and reached the lowest at 2 hours post burn. In dry exposed therapy group thedecrease in microcirculation blood flow was significantly greater than that in MEBT group. This resultproved that MEBO has microcirculation improving effect on the stasis zone of burn tissue. Thus itlessens the progressive injury in the wound at early stage and significantly increases the surviving area inthe stasis zone.