1207例门诊泌尿生殖道感染者性病病原学检测分析

Detection of pathogens causing sexually transmitted diseases of the urogenital system in 1207 cases

目的:调查医院性病和妇产科门诊患者沙眼衣原体(CT)、解脲支原体(UU)、淋球菌(NG)所致的感染情况,确定性传播疾病(STD)防治的高危人群。方法:采用荧光定量PCR方法对荆州市中心医院2006年1月～2007年10月性病门诊和妇产科门诊就诊的1 207例STD疑似患者留取的分泌物CT、UU、NG进行检测,比较不同性别、不同年龄以及其混合感染的情况。结果:3种性病病原体总阳性率为48.30%,女性(56.28%)明显高于男性(29.75%)(P<0.01),男性CT-DNA阳性率明显高于女性(P<0.05),UU-DNA阳性率明显低于女性(P<0.01);女性CT+UU、UU+NG、CT+UU+NG 3种病原体的混合感染率均高于男性,但差异无统计学意义(P>0.05);3种病原体总感染率以18～50岁年龄组较高(P<0.01),各年龄段NG-DNA感染差异无统计学意义(P>0.05),CT-DNA、UU-DNA感染差异有统计学意义(P<0.05)。结论:荆州市中心医院STD疑似患者CT、UU、NG等3种病原体的感染率较高,总阳性检出率为48.30%,混合感染率较高,感染年龄以18～40岁者居多,女性较为严重。

Objective： To explore pathogen infection of chlamydia trachomatis（CT）,ureaplasma urealyticum（UU）,neisseria gonorrhoeae（NG） in sexually transmitted diseases（STD） and maternity clinics outpatients.Confirm the high risk population of STD prevention and cure.Methods： The CT,UU,NG of secretion in 1207 suspected STD cases in STD and maternity clinics from January 2006 to October 2007 were detected by the means of fluorescent quantitative PCR.Results：Total positive rate was 48.30%,positive rate in female was higher than that in male（56.28% vs 29.75%,P〈0.01）,positive rate of CT-DNA in male was higher than that in female（P〈0.05）,positive rate of UU-DNA in male was lower than that in female（P〈0.01）;Mixture infection rates of 3 pathogens（CT＋UU,UU＋NG,CT＋UU＋NG） in female were much more than that in male,while had no statistics significance（P〉0.05） between them.Total infection rate of 3 pathogens in 18-50 age group was higher than that of others（P〈0.01）.There were statistics significance among each aged group on infection of CT-DNA and UU-DNA（P〈0.05）.Conclusion：Infection rates of CT,UU,NG pathogens in suspected STD cases from Jingzhou Centre Hospital are relatively higher.Total positive rate is 48.30%,mostly are cases of mixture infection,most of the infected cases are at age from 18 to 40;female are more severely.