闭合性颅脑外伤患者事件相关电位的研究

Study on event-related potential in patients with closed head injury

目的：研究ERP对闭合性颅脑外伤患者脑认知功能变化的评估作用。方法：应用Medicid-03E脑诱发电位仪测定168例闭合性颅脑外伤患者的视觉（图像）、听觉诱发的P3波之潜伏期和波幅，并与正常对照组作比较，54例患者进行复测比较。结果：病人组P3潜伏期较正常对照组明显延长（P＜0．001），波幅降低；P3波潜伏期、波幅与患者病情严重程度相关；有原发昏迷者改变尤为突出；随着病情的好转，P3潜伏期逐渐缩短，波幅亦逐渐增高。结论：ERP是测定闭合性颅脑外伤患者脑认知功能变化的一项客观指标。

Objectives:To assess the effect of ERP on the cognition function in potents with closed head in'jury. Methods: With Medicid-03E brain evoked potential instnnnent of Neuronic Compeany, the latency and the amplitude of P3 evoked by vistal (image) and auditory stimuli were recorded in 168 patient with closed head injury and compared with nounal subjects, 54 cases of the patients were re-examined Results: The P3 latercy in patient group was significantly prolonged as compared with the control group (P＜0.001), but the amplitude was decreased. Both the latency and the amplitude were related to the Seventy of the disease, espeially in patients with idiopathic coma.With the improvement of the disease, the latency was decreased and the amplitude increased gradually. Conchusions:ERP might be taken as an objective index of measuring the changes of the brain cognition function in patients with closed head injurp.