丙基桥联双二茂铁基查尔酮衍生物的合成

Synthesis of propyl-bridged biferrocenyl chalcone

查尔酮及其衍生物是芳香醛酮发生交叉羟醛缩合的产物,是一类重要的药物活性化合物。本文以氢氧化钠为催化剂,合成了6个丙基桥联双二茂铁基查尔酮衍生物。产物结构经1HNMR,IR及质谱进行了表征。此方法反应时间短,产率高且易于操作。

Chalcones are products of the cross-aldol condensation of ketones and aldehydes.Chalcones and their derivatives are important pharmaceutical active compounds.In this paper,seven new compounds of propyl-bridged biferrocenyl chalcone were synthesized using the catalyst of sodium hydroxide.All of these compounds were determined by MS,IR and 1HNMR spectra.This method has the advantages of short reaction times,good yields and easy operation.