心源性胸痛患者肌酸激酶同工酶和心脏型脂肪酸结合蛋白的关联性研究

Relevance between Creatine Kinase Isoenzyme-MB and Heart-Type Fatty Acid Binding Protein in Patients with Cardiac Chest Pain

目的探讨心源性胸痛患者肌酸激酶同工酶(CK-MB)和心脏型脂肪酸结合蛋白(H-FABP)的关联性。方法收治因急性胸痛症状发生在最近的12h内且持续时间至少30min的汉族、维吾尔族等民族的450例患者,入院即刻采血,使用H-FABP试剂盒定性检测H-FABP,采用BeckmanCoulterDC-800全自动生化检测仪检测CK-MB等心肌标志物。将H-FABP试剂盒检测结果与CK-MB结果进行比较,分别计算不同民族、不同时间窗H-FABP和CK-MB的Pearson列联系数,比较它们的关联性。结果所有患者的H-FABP和CK-MB的Pearson列联系数r=0.7062,差异有统计学意义。6h以内时间窗的H-FABP和CK-MB的Pearson列联系数r=0.6594,差异有统计学意义;6～12h时间窗的H-FABP和CK-MB的Pearson列联系数r=0.8067,差异有统计学意义。汉族患者的H-FABP和CK-MB的Pearson列联系数r=0.8974,差异有统计学意义;维吾尔族患者的H-FABP和CK-MB的Pearson列联系数r=0.6715,差异有统计学意义;其他民族患者的H-FABP和CK-MB的Pearson列联系数r=0.4234,差异有统计学意义。结论时间窗为0～12h的不同民族的心源性胸痛患者H-FABP和CK-MB均具有关联性。

Objective To study the correlation between creatine kinase isoenzyme -MB （CK -MB） and heart -type fatty acid binding protein （ H - FABP） in patients with cardiac chest pain. Methods Totally 450 patients of Han, Uygur and other minorities with acute chest pain occurred within 12h and with at least 30 min continuity were admitted as the subjects. The blood was sampled as soon as they were admitted. H - FABP detection kit and Beckman Coulter DC - 800 automatic biological chemical detectors were used to detect H -FABP, CK -MB and other myocardial markers. The Pearson contingency coefficients of H - FABP and CK - MB of different nationalities and at different time windows were calculated, and the correlation between H - FABP and CK - MB was compared. Results H - FABP and CK - MB for all the patients were positively correlated, with significant difference （Pearson contingency coefficient r = 0. 7062）. H - FABP and CK - MB within 6h was positively correlated （r =0.6594）, so were H-FABP and CK-MB at 6-12h （r=0.8067）, H-FABP and CK-MB for Han patients （r = 0. 8974）, H - FABP and CK - MB for Uygur patients （ r = 0. 6715 ）, and H - FABP and CK - MB for other minorities （ r = 0. 4234）, all with a significant difference. Conclusion There is significant correlation between H - FABP and CK - MB within 0 - 12 hours in patients of all nationalities with cardiac chest pain. Conclusion There is significant difference between H - FABP and CK - MB in all patients with chest pain within 0 - 12 hours.