摘要
癫痫是一种以神经活动同步性异常增高为特征的中枢神经系统疾病。我们利用基于局域一致性(regional homogeneity,ReHo)分析方法的功能磁共振成像(functional Magnetic Resonance Imaging,fMRI)技术对原发全面性癫痫(idiopathic generalized epilepsy,IGE)进行研究。观察IGE患者相比正常对照组局域一致性的改变情况。结果表明:在静息状态下,患者大脑的局域一致性在某些脑区较正常人低,主要集中在楔前叶、内侧前额叶、双侧颞叶、双侧额中回;另外,在某些脑区较正常人高,主要集中在底丘脑等中缝核团。提示该方法可检出癫痫活动造成的局部脑组织血氧水平依赖(blood oxygen level dependent,BOLD)信号同步性的改变,从而有助于原发全面性癫痫的病理生理机制的探索。
Epilepsy is a common neurological disorder characterized by abnormal hyper - synchronization of neural activity. In this study, a data processing technology of rest- state tMRI, named regional homogeneity （ReHo） was used to investigate idiopathic generalized epilepsy （IGE）. ReHo maps of each patients and healthy controls were generated respectively. Compared to the controls, the patients exhibited decreased ReHo mainly in the precuneus, medial prefrontal cortex, bilateral middle temporal gyrus and middle frontal gyrus; while the increased ReHo was mainly distributed in the subthalamus. The results indicate that ReHo can detect the abnormal regional homogeneity of the BOLD signals caused by epilepsy, and may be helpful for look into the pathophysiological mechanism of idiopathic generalized epilepsy.
出处
《生物医学工程研究》
2009年第3期167-170,共4页
Journal Of Biomedical Engineering Research
基金
国家自然科学基金资助项目(30470510
30670600
30800264)
南京军区医药卫生项目(07z030
Q2008063)
关键词
功能磁共振
局域一致性
肯德尔和谐系数
原发全面性癫痫
病理生理机制
Functional MRI
Regional homogeneity
Kendall＇s coefficient of concordance
Idiopathic generalized epilepsy
Pathophysiological mechanism
