健康管理对老年男性动脉粥样硬化的影响

The effects of health management on the development of atherosclerosis in elder men

目的探讨健康管理对老年男性动脉粥样硬化的影响。方法选择至少具有2项动脉粥样硬化危险因素的老年男性259名，随机分为健康管理组（n=131）和对照组（n=128），于入组当时和健康管理12个月后分别测量肱．踝脉搏波速度（baPWV）、颈动脉内膜中层厚度（CIMT）、血管扩张（FMD）及血脂、血糖、血压等指标，并进行健康问卷。结果两组基线数据的比较差异无统计学意义。健康管理组干预后的血压、baPWV、FMD、空腹血糖、总胆固醇、低密度脂蛋白胆固醇（LDL—C）较干预前改善（P均〈0．05），对照组变化差异无统计学意义（P均〉0．05）；干预后健康管理组的血压、baPWV、空腹血糖、总胆固醇改善优于对照组（P均〈0．05）。健康管理组的生活方式改善比对照组明显，也更愿意接受健康管理。结论针对动脉粥样硬化危险因素进行健康管理对老年男性动脉粥样硬化的进展有遏制作用。

Objective To study the effects of health management on atherosclerosis in elderly men. Methods A total of 259 elderly men with at least 2 risk factors of atherosclerosis were randomly assigned to the health management group （n = 131 ） or the control group （n = 128）. Brachial-ankle pulse wave velocity （baPWV）, carotid intima-media thickness （CIMT）, flow mediated dilation （FMD）, serum lipid profile, fasting blood glucose （FBG）, and blood pressure （BP） were measured at baseline and 12 months after intervention. Results There was no difference in clinical data between the two groups at baseline. In the health management group, the BP, baPWV, FMD, FBG, total cholesterol （TC）, low-density lipoprotein cholesterol （LDL-C） were significantly improved at 12 months （all P 〈 0.05 ） , which was not observed in the control group （ all P 〉 0.05）. After the intervention, the BP level, baPWV, FBG, and TC of the health management group were significantly improved than those of the control group （ all P 〈 0. 05 ）. The participants in the health management group experienced better life style and more interesting in receiving health management. Conclusion The health management for risk factors of atherosclerosis may be useful in the prevention of the development of atherosclerosis in elderly men.