肥胖与青少年多囊卵巢综合征

Obese and Polycystic Ovary Syndrome in Adolescents

多囊卵巢综合征(PCOS)是育龄妇女常见生殖内分泌疾病。近年发现,随着儿童肥胖患病率增加,青少年PCOS发病率也逐年提高。肥胖可通过增加外周循环胰岛素水平影响PCOS发病机制,PCOS患者高雄激素血症也会增加内脏脂肪沉积。肥胖会增加与PCOS相关的代谢和心血管方面的并发症的患病风险,如胰岛素抵抗(IR)、高脂血症、高血压以及临床症状不明显的动脉粥样硬化等。早期识别青春期PCOS,有利于及时纠正、阻断其内分泌紊乱,防止近期及远期并发症发生。

Polycystic ovary syndrome （PCOS） is a common disorder among reproductive-aged women. Recent research has elucidated that as the prevalence of pediatric obsity escalates, the morbidity of polycystic ovary syndrome in adolescent females is also increasing. Obesity contributes to the pathophysiology of polycystic ovary syndrome by increasing free insulin concentrations. Hyperandrogenism in PCOS can also increase visceral fat. Obesity can increase the morbidities of associated metabolic and cardiovascular dieases including insulin resistance （IR）, dyslipidemia, hypertension and subclinical cardiovascular disease such as atherosclerosis. Early identification of adolescent polycystic ovary syndrome will help to correct and block the endocrine disorders, as well as the complications in the near future timely.