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富半胱氨酸61与妇科肿瘤

The Cyr61 and Gynecological Tumor
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摘要 富半胱氨酸61(Cyr61)是结缔组织生长因子(CCN)家族中具有代表性的成员,其富含半胱氨酸残基的分泌性肝素连接蛋白具有多模组结构。具有诱导血管生成,促进细胞黏附、转移及诱导多药耐药形成等效用,在子宫内膜癌、宫颈癌、卵巢癌、子宫肌瘤及子宫内膜异位症的发生发展中起重要作用。 Cysteine-rich 61 （Cyr61） is a representive member in the connective tissue growth factor family. It has muhimode construction that possess the function of inducing angiogenesis and promoting cell adhesion and metastasize and rhultidrug resistance. Cyr61 plays an essential role in the 16athology of the endometrial cancer, cervical cancer, ovary cancer, uterus myoma and endometriosis.
作者 彭丽秀 周昌菊
机构地区 中南大学湘雅三医院 湖南省郴州市第一人民医院中心医院
出处 《国际妇产科学杂志》 CAS 2009年第5期367-370,共4页 Journal of International Obstetrics and Gynecology
基金 湖南省科技厅资助项目(SK3047) 湖南省卫生厅科研基金(C2007-009)
关键词 富半胱氨酸61 结缔组织生长因子 肿瘤 Cysteine-rieh 61 Connective tissue growth factor Tumor
分类号 R737.3 [医药卫生—肿瘤]
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  • 1Rachfal AW, Brigstock DR. Structural and functional properties of CCN proteins [J]. Vitam Horm, 2005, 70: 69-103.
  • 2Mo FE, Muntean AG, Chen CC, et al. CYR61 (CCN1) is essential for placental development and vascular integrity [ J ]. Mol Cell Biol, 2002, 22(24): 8709-8720.
  • 3Meyuhas R, Pikarsky E, Tavor E, et al. A Key role for cyclic AMP-responsive element binding protein in hypoxia-mediated activation of the angiogenesis factor CCN1 (CYR61) in Tumor cells[J]. Mol Cancer Res, 2008, 6(9): 1397-1409.
  • 4Grote K, Salguero G, Ballmaier M, et al. The angiogenic factor CCN1 promotes adhesion and migration of circulating CD34+ progenitor cells: potential role in angiogenesis and endothelial regeneration [J]. Blood, 2007, 110(3): 877-885.
  • 5You JJ, Yang CH, Chen MS, et al. Cysteine-rich 61, a member of the CCN family, as a factor involved in the pathogenesis of proliferative diabetic retinopathy [J]. Invest Ophthalmol Vis Sci, 2009, 50 (7): 3447-2455.
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  • 8Lin MT, Chang CC, Lin BR, et al. Elevated expression of Cyr61 enhances peritoneal dissemination of gastric cancer cells through integrin alpha2beta[J]. J Biol Chem, 2007, 282(47): 34594-34604.
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国际妇产科学杂志
2009年 第5期

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