雾化吸入法治疗矽肺合并结核病人的疗效观察

Effects of Inhalation Method for Treating Silicosis-tuberculosis Patients

目的研究雾化吸入给药方法治疗矽肺合并结核病人的疗效。方法选择在南海人民医院感染科治疗的矽肺结核病人64例作为研究对象,采用就诊顺序号单双数的方法,随机将患者分为传统给药途径组30例设为对照,使用雾化吸入给药途径34例设为实验组。对照组的抗结核药物(INH、RFP、EMB、PZA)给药途径为口服给药,同时给予雾化吸入生理盐水200ml。实验组把抗结核药物(INH、RFP)后溶于200ml生理盐水中通过雾化吸入途径给药,同时给予口服安慰剂和EMB、PZA。结果实验组有2例患者无法耐受雾化吸入而退出,有32例完成全程治疗,与对照组比较实验组痰阴转率明显增加;结核空洞的闭合情况与缩小好转情况均优于对照组;临床症状的改善情况优于对照组。结论雾化吸入给药方法可以提高矽肺合并结核病人的治疗效果。

Objective To investigate the effects of inhalation method in treating silicosis-tuberculosis patients. Methods Sixty-four sili- cosis-tuberculosis patients were choosen as study object, who were randomly divided into experiment group and control group. Drugs （INH, RFP, EMB, PZA） was taken by mouth in control group, while inhaling 200 ml physiological saline contemporarily. Drugs（INH, RFP） was tak en through inhalation method in experiment group, while taking a placebo and EMB, PZA by mouth contemporarily. Results Two patients of experiment group were expiled as they couldn＇t accept the inhalation way. Thirty-two patients finished this theropy integrally. More phlegm neg ative tuberculosis patients were in experiment group than in control group. The cavitations of pulmonary tuberculosis became smaller or disap peared in experiment group. Clinical symptoms in experiment group were less serious than in control group. Conclusion Inhalation method is more effective to treat the Silicosis-tuberculosis patients.