消化性溃疡单纯修补术后临床疗效的观察

Clinical Evaluation of the Effect of Simple Closure Operation for Perforated Peptic Ulcer

目的观察消化性溃疡单纯修补术后加三联疗法的疗效。方法对2002年至2007年收治的消化性溃疡穿孔64例病人行单纯缝合修补术治疗,术后常规抗幽门螺旋杆菌治疗,并随访观察。结果术后3个月,经电子胃镜检查溃疡愈合率治疗组为95.1%(39/41),对照组为82.6%(19/23);Hp阳性率治疗组为14.6%(6/41),对照组为56.5%(13/23)。术后1年,经电子胃镜检查溃疡复发率治疗组为7.3%(3/41),对照组26%(6/23);Hp阳性率治疗组为48.8%(20/41),对照组为69.6%(16/23)。治疗组的术后溃疡复发率显著低于对照组P<0.05。结论消化性溃疡穿孔单纯修补术安全、操作时间短、术后并发症少,术后如果能接受全程内科治疗,效果满意。

Objective To evaluate the effect of simple closure operation followed by triple therapy for perforated peptic ulcer. Meth- ods 64 cases of perforated peptic ulcer treated by simple closure operation with postoperative triple therapy were followed-up and analyzed from 2002 to 2007. Results 3 month after operation, the healing rate of peptic ulcer was 95.1% in therapy group and 82.6% in the control group. 1 year after operation, the recurrence rate of peptic ulcer was 7.3% in the therapy group and 26% in the control group. The recurrence rate of therapy group was significantly higher than that of the control group （P 〈0.05）. Conclusions Simple closure operation for perforated peptic ulcer is a safe and simple method, which promises a goog prognosis for the patiens who accept eradication of H. pylori infection.