舍雷肽酶肠溶片对慢性鼻窦炎的疗效观察

Clinical Effects of Serrapeptase Enteric-coated Tablets in Treatment of Chronic Sinusitis

目的观察舍雷肽酶肠溶片对慢性鼻窦炎疾病肿胀的疗效及安全性。方法五官门诊慢性鼻窦炎病例60例,随机分为2组。实验组30例,入诊当天开始服药,每次1片,每日3次,饭后用温开水整片吞服。总疗程为14d,并同时口服克林霉素0.3g,每日2次(bid),共服6d。对照组30例,入诊当天只服用克林霉素0.3g,bid,共服6d。观察治疗后第7、14d,患者窦内部分炎症脓性分泌物、黏膜上皮化的变化,同时测试鼻窦肿胀程度。结果治疗后7d实验组和对照组窦内部分炎症脓性分泌物及黏膜上皮化的变化比较有显著差异(P<0.01),术后14d,实验组治愈率明显高于对照组,差异有非常显著意义(P<0.01)。2组均无严重不良反应发生。结论舍雷肽酶肠溶片可明显缩短慢性鼻窦炎软组织肿胀程度和时间,效果可靠,且不良反应较轻。

Objective To evaluate the efficacy and safety of serrapeptase enteric - coated tablets in the treatment of chronic sinusitis. Methods Sixty patients with chronic sinusitis from outpatient were randomly divided into treatment group （n =30, treated with serrapeptase enteric -coated tablets, 10 mg, tid, 14 d; and clindamycin 0. 3 g, bid, 7 d） and control group （ n = 30, given clindamycin 0. 3 g, bid, 7 d）. The changes epithelizationof membrane in the sinus after the patients were treated for 7 d and of inflammatory purulent secretion and 14 d was observed. And the swelling degreeof the sinus was also tested. Results The changes of inflammatory purulent secretion and epithelization of membranein the sinus after treated for 7 d in treatment group were greater than those of control group. The curative rate aftertreated for 14 d in treatment group was significantly higher than that of the control group.