回顾性分析1856份炎琥宁注射剂使用病历

Retrospective Study of 1856 Integrated Cases Used Yanhuning Injection

目的分析炎琥宁注射剂不良反应的种类和发生率,探索药物流行病学方法在药品安全性评价中的应用。方法采用病历回顾性研究方法,对本院2006年1月至2008年12月使用炎琥宁注射剂的1856份完整住院病历进行调查,用SPSS11.5进行统计分析。结果炎琥宁注射剂主要不良反应为过敏反应(发生率0.48%),其中以过敏性皮炎(0.37%)最为常见;发热(0.22%);其他不良反应包括胃肠道反应(0.11%);呼吸道反应(0.11%);心悸、胸闷、血压下降等(0.11%)。结论病历回顾性研究方法适用于药品的安全性研究。炎琥宁注射剂的常见不良反应应引起临床医师和临床药师的重视。建议国家相关部门对其不良反应进行深入研究。

Objective To analyze the types and their incidence rates of adverse drug reaction （ADR） of Yanhuning injection, and explore the application of pharmacoepidemiology methods to drug safety evaluation. Methods By means of case retrospective study, 1856 integrated cases used Yanhuning injection from 2006 - 01 to 2008 - 12 in Shilong People＇s Hospital of Dongguan were investigated. The results were statistically analyzed by SPSS （versionl 1. 5 ）. Results The main ADR of Yanhuning injection was allergic reactions （ incidence 0.48% ） , and allergic dermatitis （0. 37% ） was the most common type; other ADR types were as follow： fever （0. 22% ）, gastrointestinal reactions （ 0. 11% ）, respiratory tract reactions （0. 11% ）, heat - throb, chest distress, and BP reduce （0.11% ）. Conclusion Case retrospective study method is suitable for drug evaluation. Doctors and pharmacist should pay more attention to the common ADR of Yanhuning injection.