痰热清联合酚妥拉明注射液治疗小儿急性下呼吸道感染临床疗效观察

Clinical Effect of Phentolamine and Tanreqing Injection in the Treatment of Children with Acute Lower Respiratory Tract Infection

目的观察注射用酚妥拉明联合痰热清治疗小儿急性下呼吸道感染临床效果。方法将64例小儿急性下呼吸道感染随机等分为治疗组和对照组，治疗组是在常规治疗（对照组）基础上加用酚妥拉明和痰热清静脉滴注治疗，酚妥拉明每次剂量（0.3～0．5）mg／（kg·次），每天1-2次，连续使用5～7d，痰热清每次剂量（0．5～0．8）mL/（kg·次），每天1次，连续使用5～7d。观察两组治疗后发热、咳嗽、喘息及肺部阳性体征消失时间。结果治疗组发热、咳嗽、喘息及肺部阳性体征消失时间均明显短于对照组（P〈0．05），两组临床疗效比较差异具有统计学差异（P〈0．05）。结论痰热清联合酚妥拉明注射液治疗小儿急性下呼吸道感染疗效好，安全性高，值得临床借鉴使用。

Objective To observe the effects and reliability of phentolamine and tanreqing injection in the treatment of children with acute lower respiratory tract infection. Methods Sixty-four cases of acute lower respiratoly tract infection were randomly divided into treatment group and control group. Both groups were given conventional therapy and the treatment group added intravenous phentolamine（0.3 - 0.5）mg/（kg.times）, 1 or 2 times a day,for（5 - 7）days and tanreqing（0.5 - 0.8mL）/（kg.times）, 1 time a day,for（5 - 7）days. The two groups were observed in the disappearance time of fever,cough,wheezing and positive signs of of the lungs after treatment. Results The disappearance time of fever,cough,wheezing and positive signs of the lungs in the treatment group was significantly shorter than that in the control group（P〈0.05）, and the clinical efficacy between the two groups showed a significant difference（P〈 0.05）. Conclusion Besides the application of conventional therapy,phentolamine and tanreqing injection in the treatment of children with acute lower respiratory tract infection and heart failure show efficacy,and safety,and it is worth clinical use.