儿童肠易激综合征3种治疗方法比较

Comparision of therapeutic effects of 3 regimens for irritable bowel syndrome

目的 探讨儿童肠易激综合征的治疗。方法 对2007年7月-2007年12月在西安市第四医院儿科门诊被诊断为肠易激综合征的75例儿童进行研究，并随机分为金双歧治疗组（30例），四磨汤治疗组（30例）和颠茄片治疗组（15例），观察不同治疗组儿童的腹痛缓解所需时间、停药后疗效持续时间、大便频率改善时间、大便性状改善时间和腹胀改善时间。结果 四磨汤治疗组腹痛缓解所需时间、停药后疗效持续时间、大便频率改善时间、大便性状改善时间和腹胀改善时间依次为4.0±2.0天、2.0±1.0月、4.0±2.0天、5.0±1.0天和4.0±3.0天，金双歧治疗组依次为5.0±2.0天、2.0±1.0月、5.0±2.0天、5.0±2.0天和4.0±1.0天，颠茄片治疗组依次为0.5±0.5天、2.0±1.0天、7.0±2.0天、8.0±4.0天和7.0±4.0天。3种治疗方法进行比较，金双歧治疗组和四磨汤治疗组儿童除腹痛缓减时间长，其余各观察指标均明显优于颠茄片治疗组，比较均有统计学意义（t=2.28-4.74，均P〈0.05），而金双歧治疗组和四磨汤治疗组各观察指标比较无显著性差别（t=0-1.936，均P〉0.05）。结论 微生态和中成药制剂治疗肠易激综合征是可行的临床治疗方法。

Objective To explore an available therapy for irritable bowel syndrome（IBS）. Methods 75 children who were diagnozed as IBS in clinic of pediatrics in our hospital over a period from July to December, 2007 were selected and randomly divided into oral golden bifid therapy group（n=30）, decoction of fourdrug juice therapy group（n=30） and belladonna therapy group（n=15）. The relieved time of stomachache, duration of therapeutic effect after stopping the therapy, improved time of stool frequency, improved time of stool character, improved time of abdominal distension of all children in the three groups were observed and compared. Results The relieved time of stomachache, duration of therapeutic effect after stopping the therapy, improved time of stool frequency, improved time of stool character, improved time of abdominal distension of children in the decoction of fourdrug juice therapy group were 4.0±2.0 days,2.0±1.0 months,4.0±2.0 days,5.0±1.0 days and 4.0±3.0 days respectively, those in oral golden bifid therapy group were 5.0±2.0 days,2.0±1.0 months,5.0±2.0 days,5.0±2.0days and 4.0±1.0 days respectively and those in the belladonna therapy group were 0.5±0.5 days,2.0±1.0 days,7.0±2.0 days,8.0±4.0 days and 7.0±4.0 days respectively. There were no significant differences between the decoction of fourdrug juice therapy group and the oral golden bifid therapy group in all obverved indexes （t=0-1.936,all P〉0.05）, while as compared with the belladonna therapy group, all observed indexes except the relieved time of stomachache in these two groups were better and the differences were significant （t=2.28-4.74,all P〈0.05）. Conclusion Microecology and Chinese patent medicine preparation are feasible therapies for IBS.