摘要
目的:观察宁夏枸杞多糖对二乙基亚硝胺诱癌作用的影响。方法:将27只Wistar成年雄性大鼠分为:(1)阴性对照组,(2)阳性对照组和(3)枸杞多糖组,(2)、(3)组饮含100mg/L浓度的二乙基亚硝胺的水溶液,(3)组每周用含10%枸杞多糖水溶液按每次0.5ml/100g体重灌胃2次,14周后处死大鼠,测血、肝中丙二醛、谷胱甘肽过氧化物酶及超氧化物歧化酶活性,肝脏作病检。结果:(2)、(3)组丙二醛含量明显高于(1)组(P<0.05);(3)组肝内超氧化物歧化酶活性高于(2)组(P<0.05),谷胱甘肽过氧化物酶各组差异不明显;(1)组肝脏病变不明显,(2)组全部肝硬变(5例合并肝癌),(3)组全部肝硬变。结论:枸杞多糖通过降低丙二醛含量,增高超氧化物歧化酶活性,提高机体抗氧化物能力。
Object:To observe the influence of Lycium Barbarum L. polysaccharide on liver cancer induced by diethylinitrosamine(DEN).Method:27 adult Wistar rats were divided into 3 groups ,(1) no treated control group,(2) exposed to DEN by drinking 100mg/L DEN water freely,(3) treated by DEN and 10% LBPL (0.5ml/100g BW/3.5d).After 14 weeks,the activities of SOD and GSH Px,and MDA content in blood and liver were determined and liver were examined under microscope.Result:The MDA content in blood of rats exposed to DEN was increased (P<0 05),activity of SOD was increased in both blood and liver of rats treated with LBLP (P<0.05),but the changes in activity of GSH Px was not markedly in statistics.In the (1) group there were no pathological changes in liver,in (2) all rats suffered cirrhosis and 5 rats were with liver cancer and in (3) all rats suffered cirrhosis and no one suffered liver cancer.Conclusion:The result suggest that LBLP could increase the ability of antioxidant in Wistar rats by decreasing the MDA content and increasing the activity of SOD and resist the inducing effect of liver cancer by DEN.
出处
《山西中医》
1998年第6期33-34,共2页
Shanxi Journal of Traditional Chinese Medicine
基金
国家自然科学基金
关键词
枸杞多糖
DEN
肝硬变
肝癌
肿瘤抑制作用
Lycium Barbarum L.Polysaccharide,diethylinitrosamine,cirrhosis,liver cancer,MDA,SOD,resist