腹腔镜与开腹结直肠癌手术对血浆血管内皮生长因子水平的影响

The effects of laparoscopic and open colorectal surgery on plasma levels of vascular endothelial growth factor

目的:评估腹腔镜与开腹结直肠癌根治术对患者血浆血管内皮生长因子(vascu lar endothelial growth factor,pVEGF)水平的影响。方法:回顾分析2007年7月至2008年2月北京医院胃肠外科收治的104例结直肠癌患者的临床资料,腹腔镜组30例,开腹组74例,分别于术前1d和术后1、3、7d采集并分离血浆,用ELISA方法检测pVEGF水平变化。结果:两组术前pVEGF分别为(82.1±79.8)ng/L和(85.9±93.8)ng/L;术后1、3、7d:腹腔镜组分别为(94.8±97.9)ng/L、(108.8±83.1)ng/L和(122.5±90.4)ng/L,开腹组分别为(109.6±99.6)ng/L、(123.5±108.7)ng/L和(133.8±110.7)ng/L。结论:腹腔镜与开腹结直肠癌根治术术后pVEGF水平均较术前升高,腹腔镜组升高幅度略低于开腹组,但两组间差异无统计学意义;各组内术后pVEGF水平升高明显,差异有统计学意义(P=0.00)。

Objective：To investigate the effects of laparoscopic and open colorectal surgery on plasma levels of vascular endothelial growth factor（pVEGF）.Methods：Clinical data of 104 cases suffered from colorectal cancer from Jul.2007 to Feb.2008 were retrospectively analyzed.There were 30 cases in laparoscopic group and 74 cases in open group.Plasma of patients on the day before operation and on the 1,3 and 7 days after operation was collected.pVEGF levels were detected by ELISA.Results：Regardless of surgical method,the postoperative pVEGF was higher than the preoperative. But there was not statistically significant difference between two groups（P 〉 0. 05 ）. The postoperative pVEGF level of open surgery and laparoscopic group were all increased（P = 0.00）. Conclusions： The pVEGF level increased after laparoscopic and open surgery, after operations the pVEGF of the laparoscopic group was less than that of the open group. But the difference of two groups pVEGF level was not significant. The postoperative pVEGF level of laparescopic and open surgery group was higher than preoperative pVEGF level respectively,and the differences were significant （P =0.00）.